Multiple Sclerosis (MS)

2007-04-29T12:47:00.000+01:00

This review is a pragmatic attempt to highlight recent research and background material in MS. It should not be considered exhaustive, simply a way of reviewing some of the major developments and current thinking in the area.

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Evidence-Based Reports

Natalizumab reduces relapse and disability in relapsing multiple sclerosis. POEMs, 2006
Intravenous immunoglobulin for MS. Bandolier, 2005
Modafinil was a safe treatment for MS fatigue, but its efficacy remains to be determined. Neurology CATs, 2004
The McDonald's MRI criteria may be useful for the early diagnosis of MS in patients presenting with a clinically isolated neurological syndrome. Neurology CATs, 2004
Good communication with healthcare providers helped patients with multiple sclerosis to cope and adapt. Evidence-Based Nursing (Requires free registration), 2004

Clinical Guidelines

Systematic Reviews

Amantadine for fatigue in multiple sclerosis. Cochrane Database of Systematic Reviews, 2007
Cyclophosphamide for multiple sclerosis. Cochrane Database of Systematic Reviews, 2007
Dietary interventions for multiple sclerosis. Cochrane Database of Systematic Reviews, 2007
Treatment for ataxia in multiple sclerosis. Cochrane Database of Systematic Reviews, 2007
Mitoxantrone for multiple sclerosis. Cochrane Database of Systematic Reviews, 2005
Psychological interventions for multiple sclerosis. Cochrane Database of Systematic Reviews, 2005
Sativex for the management of multiple sclerosis symptoms. Health Technology Assessment, 2005
Accuracy of magnetic resonance imaging for the diagnosis of multiple sclerosis: systematic review. DARE, 2006
Home versus outpatient administration of intravenous steroids for multiple-sclerosis relapses: a randomised controlled trial. NHS EED, 2006

Recent articles in core journals

Longitudinal follow-up of "benign" multiple sclerosis at 20 years. Neurology, 2007
Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol, 2007
Effectiveness of non-pharmacological interventions for fatigue in adults with multiple sclerosis, rheumatoid arthritis, or systemic lupus erythematosus: a systematic review. J Adv Nurs, 2006
Lack of association between antimyelin antibodies and progression to multiple sclerosis. NEJM, 2007
Clinical and demographic predictors of long-term disability in patients with relapsing-remitting multiple sclerosis: a systematic review. Arch Neurol, 2006
Prognostic factors for early severity in a childhood multiple sclerosis cohort. Pediatrics, 2006
Accuracy of magnetic resonance imaging for the diagnosis of multiple sclerosis: systematic review. BMJ, 2006
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA, 2006
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. NEJM, 2006
Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. NEJM, 2006
Diagnosis and Management of Multiple Sclerosis. American Family Physician, 2004

eTextbooks

Clinical Queries

For a woman using combined oral contraception, is there any evidence to suggest a contraindication to the use of Interferon beta for treatment of multiple sclerosis? Faculty of Family Planning & Reproductive Health Care Q&A, 2006
For a woman who is immobilised as a result of multiple sclerosis, is there any evidence that there may be increased symptoms with a reduction in oestroegn with the use of progestogen only injectables? Faculty of Family Planning & Reproductive Health Care Q&A, 2005
Should all patients with multiple sclerosis have Vit D levels monitored and be given therapeutic doses if below normal levels to reduce incidence of relapse? NLH Q&A Service, 2005
Should a patient with multiple sclerosis be given the influenza vaccination? NLH Q&A Service, 2005
It is recommended that patients with multiple sclerosis have their eyes tested regularly. Are there any published guidelines on how frequently this should be done? NLH Q&A Service, 2006
How suitable are IUDs (non-hormonal) for patients with multiple sclerosis? NLH Q&A Service, 2006

Patient Information

TRIP Evidence Reviews: MS

Multiple Sclerosis (MS)